José G. Venegas

Ventilation Defect Formation in Healthy and Asthma Subjects Is Determined by Lung Inflation

Published on 2012-12-28 in PLoS ONE, vol 7. DOI: 10.1371/journal.pone.0053216
Background Imaging studies have demonstrated that ventilation during bronchoconstriction in subjects with asthma is patchy with large ventilation defective areas (Vdefs). Based on a theoretical model, we postulated that during bronchoconstriction, as smooth muscle force activation increases, a patchy distribution of ventilation should emerge, even in the presence of minimal heterogeneity the lung. We therefore theorized that in normal lungs, Vdefs should also emerge in regions… Read more