Integrating precision medicine in the study and clinical treatment of a severely mentally ill person

Published on 2013-10-03 in PeerJ, vol 1. DOI: 10.7717/peerj.177
Background. In recent years, there has been an explosion in the number of technical and medical diagnostic platforms being developed. This has greatly improved our ability to more accurately, and more comprehensively, explore and characterize human biological systems on the individual level. Large quantities of biomedical data are now being generated and archived in many separate research and clinical activities, but there exists a paucity of studies that integrate the areas of clinical… Read more

Using Pattern Classification to Measure Adaptation to the Orientation of High Order Aberrations

Published on 2013-08-14 in PLoS ONE, vol 8. DOI: 10.1371/journal.pone.0070856
BackgroundThe image formed by the eye's optics is blurred by the ocular aberrations, specific to each eye. Recent studies demonstrated that the eye is adapted to the level of blur produced by the high order aberrations (HOA). We examined whether visual coding is also adapted to the orientation of the natural HOA of the eye.Methods and FindingsJudgments of perceived blur were measured in 5 subjects in a psychophysical procedure inspired by the “Classification Images” technique. Subjects… Read more

Impairment in Task-Specific Modulation of Muscle Coordination Correlates with the Severity of Hand Impairment following Stroke

Published on 2013-07-16 in PLoS ONE, vol 8. DOI: 10.1371/journal.pone.0068745
Significant functional impairment of the hand is commonly observed in stroke survivors. Our previous studies suggested that the inability to modulate muscle coordination patterns according to task requirements may be substantial after stroke, but these limitations have not been examined directly. In this study, we aimed to characterize post-stroke impairment in the ability to modulate muscle coordination patterns across tasks and its correlation with hand impairment. Fourteen stroke… Read more