Using Pattern Classification to Measure Adaptation to the Orientation of High Order Aberrations

Published on 2013-08-14 in PLoS ONE, vol 8. DOI: 10.1371/journal.pone.0070856
BackgroundThe image formed by the eye's optics is blurred by the ocular aberrations, specific to each eye. Recent studies demonstrated that the eye is adapted to the level of blur produced by the high order aberrations (HOA). We examined whether visual coding is also adapted to the orientation of the natural HOA of the eye.Methods and FindingsJudgments of perceived blur were measured in 5 subjects in a psychophysical procedure inspired by the “Classification Images” technique. Subjects… Read more

Impairment in Task-Specific Modulation of Muscle Coordination Correlates with the Severity of Hand Impairment following Stroke

Published on 2013-07-16 in PLoS ONE, vol 8. DOI: 10.1371/journal.pone.0068745
Significant functional impairment of the hand is commonly observed in stroke survivors. Our previous studies suggested that the inability to modulate muscle coordination patterns according to task requirements may be substantial after stroke, but these limitations have not been examined directly. In this study, we aimed to characterize post-stroke impairment in the ability to modulate muscle coordination patterns across tasks and its correlation with hand impairment. Fourteen stroke… Read more

Time-Integrated Position Error Accounts for Sensorimotor Behavior in Time-Constrained Tasks

Published on 2012-03-21 in PLoS ONE, vol 7. DOI: 10.1371/journal.pone.0033724
Several studies have shown that human motor behavior can be successfully described using optimal control theory, which describes behavior by optimizing the trade-off between the subject's effort and performance. This approach predicts that subjects reach the goal exactly at the final time. However, another strategy might be that subjects try to reach the target position well before the final time to avoid the risk of missing the target. To test this, we have investigated whether… Read more

Ventilation Defect Formation in Healthy and Asthma Subjects Is Determined by Lung Inflation

Published on 2012-12-28 in PLoS ONE, vol 7. DOI: 10.1371/journal.pone.0053216
Background Imaging studies have demonstrated that ventilation during bronchoconstriction in subjects with asthma is patchy with large ventilation defective areas (Vdefs). Based on a theoretical model, we postulated that during bronchoconstriction, as smooth muscle force activation increases, a patchy distribution of ventilation should emerge, even in the presence of minimal heterogeneity the lung. We therefore theorized that in normal lungs, Vdefs should also emerge in regions… Read more

Continuous Three-Dimensional Control of a Virtual Helicopter Using a Motor Imagery Based Brain-Computer Interface

Published on 2011-10-26 in PLoS ONE, vol 6. DOI: 10.1371/journal.pone.0026322
Brain-computer interfaces (BCIs) allow a user to interact with a computer system using thought. However, only recently have devices capable of providing sophisticated multi-dimensional control been achieved non-invasively. A major goal for non-invasive BCI systems has been to provide continuous, intuitive, and accurate control, while retaining a high level of user autonomy. By employing electroencephalography (EEG) to record and decode sensorimotor rhythms (SMRs) induced from motor… Read more