Ventilation Defect Formation in Healthy and Asthma Subjects Is Determined by Lung Inflation
Published on 2012-12-28 in PLoS ONE, vol 7. DOI: 10.1371/journal.pone.0053216
Research Article, Medicine, Anatomy and physiology, Chemistry, Physical chemistry, Mixtures, Aerosols, Respiratory system, Respiratory physiology, Clinical research design, Statistical methods, Pulmonology, Asthma, Radiology, Nuclear medicine, PET imaging, Radionuclide imaging, Physiology, Respiratory Medicine, Radiology and Medical Imaging
Background Imaging studies have demonstrated that ventilation during bronchoconstriction in subjects with asthma is patchy with large ventilation defective areas (Vdefs). Based on a theoretical model, we postulated that during bronchoconstriction, as smooth muscle force activation increases, a patchy distribution of ventilation should emerge, even in the presence of minimal heterogeneity the lung. We therefore theorized that in normal lungs, Vdefs should also emerge in regions…
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